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KMID : 0351619700110020317
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Kyungpook Medical Journal
1970 Volume.11 No. 2 p.317 ~ p.327
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Experimental Study on the Effects of the Subconjunctival Injections of α-Chymotrypsin and Hypertonic Saline Solutions to the Intra-vitreally Injected Blood
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Abstract
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The intra-vitreal hemorrhage is a commonly seen condition at ophthalmologists´ offices and it occurs as an intra=ocular manifestation and/or a complication of the systemic diseases, and as a complication of the various ocular injuries. Yet as an ophthalmologist it is a most frustrating condition to see because he can do very little for it except complete bed rest with binocular patches, cold compress in case of recent homorrhages and treatment of basic systomic diseases hoping that it would prevent further bleedings. For the purpose of encouraging the absorption of these bloods in the vitreous, the subconjunctival in jection of the hypertonic saline solution, washout of the vitreous and an intra-vitreal injection of hyalunronidase have been tried without getting much help from these. Furthermore, we have found a great deal of difficulty in finding helpful literatures on this subject.
It is the purpose of this paper to find out the effects of the subconjunctival injection of α-chymotrypsin and hypertonic saline solutions to the intravitreally injected blood. 40 rabbits weighing approx. 2kgs were used for this experiment. In the right eye of these animals, 0.1ml. and in the left eye 0.2ml. of own blood was injected respectively into the vitreous through the pars plana. These animals were divided into following four groups. In group 1.(control group), no treatment was given. In group2, 0.2ml. of 3 per cent hypertonic saline solution was injected subconjuctivally every 4th day up to minimum of 168 days and maximum of 270 days. In group 3,2,000 H.U.M. of α-chymotrypsin solution, and in group 4, 0.2ml. of 3 per cent hypertonic saline and 2,000 H.U.M. of α-chymotrypsin solutions were injected subconjunctivally on every 4th day for the same period.
Following results were obtained:
1. As to the period between the dis-appearance and reappearance of the reflex of the eye ground following an intravitreal injection, no significant difference was noted among each group.
2. The intravitreally injected blood appeared in the anterior chamber of the left eye in 40 per cent of the subjects in 5.9 days on average.
3. The subconjunctvial injection of 3 per cent hypertonic saline solution was found to be helpful in the absorption of the intravitreally injected blood in the right eye in which 0.1ml. of blood was injected, but it was not helpful in the left eye in which 0.2ml. was injected.
4. The absorption of the blood was not only enhanced remarkablly in those groups in which α-chymotrypsin was given subconjunctivally, but being compared with the control group, the formation of inflammatory membraned in the vitreous was less severe.
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